Pyrroloquinoline quinone (Synonyms: 吡咯喹啉醌; Methoxatin)
Pyrroloquinoline quinone 是氧化還原輔助因子,一種陰離子型氧化還原循環(huán)原醌。Pyrroloquinoline quinone 最初是從嗜甲基細(xì)菌的培養(yǎng)物中分離的,也存在于哺乳動物的組織。Pyrroloquinoline quinone 是哺乳動物的必需營養(yǎng)素,對免疫功能很重要。
生物活性
Pyrroloquinoline quinone , a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function[1][2].
IC50 & Target[1]
Human Endogenous Metabolite
體外研究(In Vitro)
Mouse pups born to and nursing from Pyrroloquinoline quinone-deprived dams have a compromised immune response as well as alopecia, a hunched posture, and a susceptibility to aortic aneurysms[2].
分子量:330.21
Formula:C14H6N2O8
CAS 號:72909-34-3
中文名稱:吡咯喹啉醌;吡咯并喹啉苯醌
來源:prokaryotes
運(yùn)輸條件:Room temperature in continental US; may vary elsewhere.
儲存方式:
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
溶解性數(shù)據(jù)
H2O : 1 mg/mL (3.03 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
---|
1 mM | 3.0284 mL | 15.1419 mL | 30.2838 mL |
5 mM | --- | --- | --- |
10 mM | --- | --- | --- |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 儲存時(shí),請?jiān)?6 個(gè)月內(nèi)使用,-20°C 儲存時(shí),請?jiān)?1 個(gè)月內(nèi)使用。
參考文獻(xiàn)
[1]. Moog RS, et al. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9.
[2]. Bishop A, et al. Methoxatinin guinea-pig neutrophils. Free Radic Biol Med. 1994 Oct;17(4):311-20.
注:產(chǎn)品僅用于科研