地諾前列酮Prostaglandin E2 是從前列腺分泌物中分離到的一種天然的血管擴張藥,一般是通過結(jié)合并激活prostaglandin E2 receptor起作用。
PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation[1].