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β葡聚糖受體抗體Glucan Receptor齊一生物科技(上海)有限公司試劑種類眾多:覆蓋分析化學(xué)品,無(wú)機(jī)化學(xué)品,有機(jī)化學(xué)品,生物化學(xué)品,材料化學(xué)品.試劑信息齊全:包含試劑特性描述,詳細(xì)質(zhì)量信息,應(yīng)用方法、標(biāo)準(zhǔn),用途以及正在開發(fā)的前沿應(yīng)用.齊一生物科技(上海)有限公司: 60348496.www.qiyibio。。com
Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647 AP APC Biotin Cy3 Cy5
Cy5.5 Cy7 FITC Gold HRP PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 RBITC
β葡聚糖受體抗體Glucan Receptor英文名稱 beta Glucan Receptor
中文名稱 β葡聚糖受體抗體
別 名 Dectin1; Dectin-1; Dectin 1; CLECSF12; C-type lectin domain family 7 member A; beta Glucan Receptor; Beta GR; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; Clec7a; CANDF4; DECTIN1; CLEC7A protein; Clecsf12; Dectin 1; DECTIN 1 receptor; Dectin1; Dendritic cell associated C type lectin 1; Lectin like receptor 1; beta Glucan Receptor; Putative transmembrane protein dectin 1; CLC7A_HUMAN.
研究領(lǐng)域 細(xì)胞生物 免疫學(xué) 淋巴細(xì)胞
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500(石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
細(xì)胞定位 細(xì)胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dectin-1
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene plex region. [provided by RefSeq].
Function:
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).
Subunit:
Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens.
Subcellular Location:
Cell membrane; Single-pass type II membrane protein.
Tissue Specificity:
Detected in dendritic cells, in paracortical and medullary regions of lymph nodes, and in spleen red pulp and white pulp.
Post-translational modifications:
on tyrosine residues in response to glucan binding.
Similarity:
Contains 1 C-type lectin domain.
Gene ID:
64581
Database links:
Entrez Gene: 64581 Human
Entrez Gene: 56644 Mouse
Entrez Gene: 502902 Rat
Omim: 606264 Human
SwissProt: Q9BXN2 Human
SwissProt: Q6QLQ4 Mouse
Unigene: 143929 Human
Unigene: 239516 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
β-葡聚糖受體是一種非調(diào)理素依賴性受體,可在免疫反應(yīng)早期,在清除衰老細(xì)胞和防御感染方面發(fā)揮重要作用,進(jìn)而實(shí)現(xiàn)其抗腫瘤、抗感染等生物學(xué)效應(yīng)。
issue/cell: mo spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-DECTIN-1/CLECSF12/beta Glucan Receptor Polyclonal Antibody, Unconjugated (bs-2455R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining