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HY-N0184
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更新時(shí)間:2024-06-26 10:42:50瀏覽次數(shù):199次
聯(lián)系我時(shí),請告知來自 制藥網(wǎng)CAS號 | 1405-86-3 | 產(chǎn)地 | 國產(chǎn) |
---|---|---|---|
規(guī)格 | 50mg | 級別 | 化工級 |
證書 | ISO系列證書 |
Glycyrrhizic acid 是甘草里面的活性成分三萜皂苷,為 HMGB1 的拮抗劑,有用于zhong瘤、糖尿病等研究的潛力。
生物活性
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
體外研究(In Vitro)
Glycyrrhizic acid shows a series of anti-cancer-related pharmacological activities, such as broad-spectrum anti-cancer ability, resistance to the tissue toxicity caused by chemotherapy and radiation, drug absorption enhancing effects and anti-multidrug resistance (MDR) mechanisms, as a carrier material in drug delivery systems[1].
In intestinal NCI-H716 cells that secretes GLP-1, Glycyrrhizic acid promotes GLP-1 secretion with a marked elevation of calcium levels. Glycyrrhizic acid can enhance GLP-1 secretion through TGR5 activation[2].
Glycyrrhizic acid can form a stable transparent low-molecular-weight hydrogels (LMWHs) at 37°C in physiological phosphate buffered saline (PBS) with nanoclusters as the microstructures[4].
體內(nèi)研究(In Vivo)
n type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), Glycyrrhizic acid increases the level of plasma GLP-1, which is blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-coupled receptor 5 (TGR5)[1]. Glycyrrhizic acid (Glycyrrhizic acid; 50 mg/kg, i.p.) significantly decreases the levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β in mice[3].
分子量:822.93
Formula:C42H62O16
CAS 號:1405-86-3
中文名稱:甘草酸;甘草皂甙;甘草甜素;強(qiáng)力寧;甘草皂苷
運(yùn)輸條件:Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder | -20°C | 3 years |
---|---|---|
4°C | 2 years | |
In solvent | -80°C | 6 months |
-20°C | 1 month |
溶解性數(shù)據(jù)
DMSO : 500 mg/mL (607.59 mM; Need ultrasonic)
H2O : < 0.1 mg/mL (insoluble)
濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
---|
1 mM | 1.2152 mL | 6.0759 mL | 12.1517 mL |
5 mM | 0.2430 mL | 1.2152 mL | 2.4303 mL |
10 mM | 0.1215 mL | 0.6076 mL | 1.2152 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí),請?jiān)?6 個(gè)月內(nèi)使用,-20°C 儲(chǔ)存時(shí),請?jiān)?1 個(gè)月內(nèi)使用。
以下溶解方案都請先按照 In Vitro 方式配制澄清的儲(chǔ)備液,再依次添加助溶劑:
——為保證實(shí)驗(yàn)結(jié)果的可靠性,澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件,適當(dāng)保存;體內(nèi)實(shí)驗(yàn)的工作液,建議您現(xiàn)用現(xiàn)配,當(dāng)天使用; 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比;如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象,可以通過加熱和/或超聲的方式助溶
請依序添加每種溶劑: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 22.5 mg/mL (27.34 mM); Clear solution
請依序添加每種溶劑: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 10 mg/mL (12.15 mM); Suspended solution; Need ultrasonic
請依序添加每種溶劑: 10% DMSO 90% corn oil
Solubility: 10 mg/mL (12.15 mM); Suspended solution; Need ultrasonic
參考文獻(xiàn)
[1]. Su X, et al. Glycyrrhizic acid: A promising carrier material for anticancer therapy. Biomed Pharmacother. 2017 Sep 5;95:670-678 [Content Brief]
[2]. Wang LY, et al. Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats. Biomed Pharmacother. 2017 Sep 4;95:599-604. [Content Brief]
[3]. Li C, et al. Glycyrrhizin, a Direct HMGB1 Antagonist, Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling. Thyroid. 2017 May;27(5):722-731. [Content Brief]
[4]. Xia Zhao, et al. A Simple Injectable Moldable Hydrogel Assembled from Natural Glycyrrhizic Acid with Inherent Antibacterial Activity. ACS Appl. Bio Mater. 2020, 3, 1, 648–653.
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