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當(dāng)前位置:杭州昊鑫生物科技股份有限公司>>MCE>> HY-P7044IL-6 蛋白, Human
HY-P7044
MCE
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杭州市
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IL-6 蛋白, Human 有效誘導(dǎo)肝細(xì)胞合成急性期蛋白,參與炎癥反應(yīng)。
描述
IL-6 Protein, Human is a potent inducer of the synthesis of acute phase proteins in adult human hepatocytes.
研究背景
Interleukin-6 (IL-6) is a 26-kD protein released by fibroblasts, T lymphocytes, endothelial cells, monocytes, and keratinocytes during inflammatory responses. IL-6 has pluripotent activities, including the stimulation of the monocytic lineage, the induction of megakaryopoiesis and the hepatic acute phase response, as well as the modulation of T- and B-cell responses. IL-6 is also capable of mediating direct and indirect tumor cell destruction and that it is potentially important for the immunotherapy of cancer[1. Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes[2].
生物活性
The ED50 is <1.0 ng/mL as measured by TF-1 cells, corresponding to a specific activity of 1× 106 units/mg.
種屬:Human
表達(dá)系統(tǒng):E. coli
標(biāo)簽:Tag Free
蛋白編號(hào):P05231 (P29-M212)
基因 ID:3569 [NCBI]
同用名:rHuIL-6; BSF-2; CDF; Hybridoma growth factor; IFN-beta-2
氨基酸序列
PVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
分子量:Approximately 21,000 Da
純度:Greater than 95% as determined by reducing SDS-PAGE.
性狀:Lyophilized powder.
組分:Lyophilized after extensive dialysis against 20 mM HAc-NaAc, pH 5.0, 150 mM NaAc buffer.
復(fù)溶方法:It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
保存條件 & 期限
Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
運(yùn)輸條件
Room temperature in continental US; may vary elsewhere.
參考文獻(xiàn)
[1]. Nieken J, et al. Recombinant human interleukin-6 induces a rapid and reversible anemia in cancer patients. Blood. 1995 Aug 1;86(3):900-5. [Content Brief]
[2]. Castell JV, et al. Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett. 1988 May 23;232(2):347-50. [Content Brief]
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